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Respiratory physiology

Ventilation & capnography

Pulse oximetry tells you about oxygenation; the capnogram tells you about ventilation, circulation and where the tube is.

Read one breath

Normal capnogram with phases I (inspiratory baseline), II (expiratory upstroke), III (alveolar plateau) and 0 (inspiratory downstroke); ETCO₂ measured at the end of phase III. 0 40 I II III 0 ETCO₂ time →

Nine patterns to recognize

Look at the trace, decide what you’d think, then reveal. Schematic waveforms — guides at 0 and ≈ 40 mmHg.

Trace fades after intubation

Schematic capnogram: Trace fades after intubation 0 40

Sudden drop to zero

Schematic capnogram: Sudden drop to zero 0 40

Sudden fall, not to zero

Schematic capnogram: Sudden fall, not to zero 0 40

Steady decline over breaths

Schematic capnogram: Steady decline over breaths 0 40

“Shark fin” — sloped upstroke, no plateau

Schematic capnogram: “Shark fin” — sloped upstroke, no plateau 0 40

Curare cleft — notch in the plateau

Schematic capnogram: Curare cleft — notch in the plateau 0 40

Baseline doesn’t return to zero

Schematic capnogram: Baseline doesn’t return to zero 0 40

Gradual rise

Schematic capnogram: Gradual rise 0 40

Ripples at end-expiration

Schematic capnogram: Ripples at end-expiration 0 40

Ventilator basics

SettingTypical starting pointWhat it changes
Tidal volume (Vt)6–8 mL/kg predicted body weightVentilation; lung stretch
Respiratory rate10–14 /min → ETCO₂ 35–45Minute ventilation (Vt × RR) → CO₂
PEEP≈ 5 cmH₂OOxygenation; prevents atelectasis
FiO₂Lowest that meets the SpO₂ targetOxygenation
ModeVolume control or pressure control; pressure support when breathing spontaneouslyWhat’s fixed vs. what varies

Oxygenation ← FiO₂ and PEEP. Ventilation (CO₂) ← rate and tidal volume. The team individualizes settings using mechanics, gas exchange and the procedure (e.g., pneumoperitoneum raises ETCO₂ and airway pressure).

Pimp questions

Pimp question 1
ETCO₂ suddenly falls from 38 to 18 mmHg with a normal-looking waveform. What are you worried about?
Answer
A sudden fall in cardiac output or pulmonary embolism (also massive hemorrhage or a large leak). Tell the team and check BP.
Pimp question 2
Why does ETCO₂ rise during laparoscopy?
Answer
CO₂ insufflated into the peritoneum is absorbed into the blood.
Pimp question 3
What does an elevated inspiratory baseline mean?
Answer
Rebreathing of CO₂ — classically an exhausted absorbent or an incompetent expiratory valve.
Pimp question 4
How do you increase CO₂ clearance on the ventilator?
Answer
Increase minute ventilation: rate and/or tidal volume.
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