Anticholinergic
Glycopyrrolate
Robinul Anticholinergic — green 0.2 mg/mL
Peripheral anticholinergic: dries secretions, pairs with neostigmine.
Typical adult doses
| Indication | Dose | Onset | Duration |
|---|---|---|---|
| With neostigmine | 0.2 mg per 1 mg neostigmine | — | — |
| Antisialagogue | 0.1–0.2 mg IV | 2–3 min | — |
Mechanism
Quaternary muscarinic antagonist.
Key effects
- ↓ secretions, modest ↑HR
Watch out for
- Tachycardia
Pimp questions
Pimp question
Why is glycopyrrolate preferred for drying secretions in the elderly?
Answer
It does not cross the BBB, so no central anticholinergic delirium.